Antibody-based cytokine mimetics emerged as promising entities in order to modulate an immune response. These surrogate agonists are bi- and multifunctional antibody-derived molecules that mimic the function of a cytokine by agonizing a specific cytokine receptor. Due to the high modularity of antibody-based building blocks, cytokine functionalities can be highly engineered, for instance with regards to signalling strength and bias.
