Becker, Linda Carmen Annabelle (2014):
Influence of repair proteins and chromatin modifiers on mobility of DNA double-strand breaks induced by heavy ion irradiation.
Darmstadt, Technische Universität,
[Ph.D. Thesis]
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Item Type: | Ph.D. Thesis | ||||
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Title: | Influence of repair proteins and chromatin modifiers on mobility of DNA double-strand breaks induced by heavy ion irradiation | ||||
Language: | English | ||||
Abstract: | Ionizing radiation induces DNA double strand breaks (DSBs) in cell nuclei which represent the most dangerous type of DNA lesions. Through error prone repair mechanisms they can lead to the formation of chromosome rearrangements, favoring genomic instability and the development of cancer. Movement of DSBs and surrounding chromatin domains is expected to influence DSB repair and promote the formation of chromosomal translocations. Addressing this expectation, DSB mobility was analyzed after heavy ion irradiation. To gain insight into influences of chromatin organization and repair related factors on the dynamic behavior of DSB sites, knockdown or inhibition of repair proteins and chromatin modifying proteins was used. Occurring changes in irradiation induced foci (IRIF) mobility were examined either by immunofluorescent analysis of fixed samples or by live cell microscopy. |
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Place of Publication: | Darmstadt | ||||
Classification DDC: | 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie | ||||
Divisions: | 10 Department of Biology 10 Department of Biology > Radiation Biology and DNA Repair |
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Date Deposited: | 14 Aug 2014 07:13 | ||||
Last Modified: | 09 Jul 2020 00:44 | ||||
URN: | urn:nbn:de:tuda-tuprints-40382 | ||||
Referees: | Durante, Prof Marco ; Thiel, Prof Gerhard | ||||
Date of oral examination: | 16 May 2014 | ||||
URI: | https://tuprints.ulb.tu-darmstadt.de/id/eprint/4038 | ||||
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