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Synthesis, Structure–Property Evaluation and Biological Assessment of Supramolecular Assemblies of Bioactive Glass with Glycyrrhizic Acid and Its Monoammonium Salt

Matchanov, Alimjon D. ; Esanov, Rakhmat S. ; Renkawitz, Tobias ; Soliev, Azamjon B. ; Kunisch, Elke ; Gonzalo de Juan, Isabel ; Westhauser, Fabian ; Tulyaganov, Dilshat U. (2022):
Synthesis, Structure–Property Evaluation and Biological Assessment of Supramolecular Assemblies of Bioactive Glass with Glycyrrhizic Acid and Its Monoammonium Salt. (Publisher's Version)
In: Materials, 15 (12), MDPI, e-ISSN 1996-1944,
DOI: 10.26083/tuprints-00021636,
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Item Type: Article
Origin: Secondary publication DeepGreen
Status: Publisher's Version
Title: Synthesis, Structure–Property Evaluation and Biological Assessment of Supramolecular Assemblies of Bioactive Glass with Glycyrrhizic Acid and Its Monoammonium Salt
Language: English
Abstract:

Medical nutrients obtained from plants have been used in traditional medicine since ancient times, owning to the protective and therapeutic properties of plant extracts and products. Glycyrrhizic acid is one of those that, apart from its therapeutic effect, may contribute to stronger bones, inhibiting bone resorption and improving the bone structure and biomechanical strength. In the present study, we investigated the effect of a bioactive glass (BG) addition to the structure–property relationships of supramolecular assemblies formed by glycyrrhizic acid (GA) and its monoammonium salt (MSGA). FTIR spectra of supramolecular assemblies evidenced an interaction between BG components and hydroxyl groups of MSGA and GA. Moreover, it was revealed that BG components may interact and bond to the carboxyl groups of MSGA. In order to assess their biological effects, BG, MSGA, and their supramolecular assemblies were introduced to a culture of human bone-marrow-derived mesenchymal stromal cells (BMSCs). Both the BG and MSGA had positive influence on BMSC growth, viability, and osteogenic differentiation—these positive effects were most pronounced when BG1d-BG and MSGA were introduced together into cell culture in the form of MSGA:BG assemblies. In conclusion, MSGA:BG assemblies revealed a promising potential as a candidate material intended for application in bone defect reconstruction and bone tissue engineering approaches.

Journal or Publication Title: Materials
Volume of the journal: 15
Issue Number: 12
Place of Publication: Darmstadt
Publisher: MDPI
Collation: 13 Seiten
Uncontrolled Keywords: bioactive glasses, glycyrrhizic acid, supramolecular assemblies, bone tissue engineering
Classification DDC: 500 Naturwissenschaften und Mathematik > 540 Chemie
500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie
Divisions: 11 Department of Materials and Earth Sciences > Material Science > Dispersive Solids
Date Deposited: 11 Jul 2022 13:27
Last Modified: 06 Sep 2022 10:42
DOI: 10.26083/tuprints-00021636
Corresponding Links:
URN: urn:nbn:de:tuda-tuprints-216368
SWORD Depositor: Deep Green
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/21636
PPN: 498914682
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