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An Additively Manufactured Sample Holder to Measure the Controlled Release of Vancomycin from Collagen Laminates

Kilb, Michelle Fiona ; Moos, Yannik ; Eckes, Stefanie ; Braun, Joy ; Ritz, Ulrike ; Nickel, Daniela ; Schmitz, Katja (2022):
An Additively Manufactured Sample Holder to Measure the Controlled Release of Vancomycin from Collagen Laminates. (Publisher's Version)
In: Biomedicines, 9 (11), MDPI, e-ISSN 2227-9059,
DOI: 10.26083/tuprints-00020067,
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Item Type: Article
Origin: Secondary publication DeepGreen
Status: Publisher's Version
Title: An Additively Manufactured Sample Holder to Measure the Controlled Release of Vancomycin from Collagen Laminates
Language: English
Abstract:

The controlled release of antibiotics prevents the spread of pathogens and thereby improves healing processes in regenerative medicine. However, high concentrations may interfere with healing processes. It is therefore advantageous to use biodegradable materials for a controlled release. In particular, multilayer materials enable differential release at different surfaces. For this purpose, collagen sheets of different properties can be bonded by photochemical crosslinking. Here, we present the development and application of an easily accessible, additively manufactured sample holder to study the controlled release of vancomycin from modularly assembled collagen laminates in two directions. As proof-of-concept, we show that laminates of collagen sheets covalently linked by rose bengal and green light crosslinking (RGX) can be tightly inserted into the device without leakage from the upper to lower cavity. We used this sample holder to detect the release of vancomycin from symmetrically and asymmetrically loaded two-layer and three-layer collagen laminates into the upper and lower cavity of the sample holder. We show that these collagen laminates are characterized by a collagen type-dependent vancomycin release, enabling the control of antibiotic release profiles as well as the direction of antibiotic release.

Journal or Publication Title: Biomedicines
Volume of the journal: 9
Issue Number: 11
Publisher: MDPI
Collation: 13 Seiten
Uncontrolled Keywords: collagen, controlled release, crosslinking, vancomycin, additively manufactured sample holder
Classification DDC: 500 Naturwissenschaften und Mathematik > 540 Chemie
600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin, Gesundheit
600 Technik, Medizin, angewandte Wissenschaften > 620 Ingenieurwissenschaften
Divisions: 07 Department of Chemistry > Fachgebiet Biochemie
07 Department of Chemistry > Organ Chemistry
Date Deposited: 29 Apr 2022 08:47
Last Modified: 20 May 2022 11:16
DOI: 10.26083/tuprints-00020067
Corresponding Links:
URN: urn:nbn:de:tuda-tuprints-200673
SWORD Depositor: Deep Green
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/20067
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