Hegewald, Anett B. ; Breitwieser, Kai ; Ottinger, Sarah M. ; Mobarrez, Fariborz ; Korotkova, Marina ; Rethi, Bence ; Jakobsson, Per-Johan ; Catrina, Anca I. ; Wähämaa, Heidi ; Saul, Meike J. (2021):
Extracellular miR-574-5p Induces Osteoclast Differentiation via TLR 7/8 in Rheumatoid Arthritis. (Publisher's Version)
In: Frontiers in Immunology, 11, Frontiers, e-ISSN 1664-3224,
DOI: 10.26083/tuprints-00019253,
[Article]
|
Text
Saul-fimmu-11-585282-mit.pdf Copyright Information: CC BY 4.0 International - Creative Commons, Attribution. Download (9MB) | Preview |
Item Type: | Article |
---|---|
Origin: | Secondary publication via sponsored Golden Open Access |
Status: | Publisher's Version |
Title: | Extracellular miR-574-5p Induces Osteoclast Differentiation via TLR 7/8 in Rheumatoid Arthritis |
Language: | English |
Abstract: | Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation and joint destruction. Cell-derived small extracellular vesicles (sEV) mediate cell-to-cell communication in the synovial microenvironment by carrying microRNAs (miRs), a class of small non-coding RNAs. Herein, we report that sEV from synovial fluid promote osteoclast differentiation which is attributed to high levels of extracellular miR-574-5p. Moreover, we demonstrate for the first time that enhanced osteoclast maturation is mediated by Toll-like receptor (TLR) 7/8 signaling which is activated by miR-574-5p binding. This is a novel mechanism by which sEV and miRs contribute to RA pathogenesis and indicate that pharmacological inhibition of extracellular miR-574-5p might offer new therapeutic strategies to protect osteoclast-mediated bone destruction in RA. |
Journal or Publication Title: | Frontiers in Immunology |
Volume of the journal: | 11 |
Place of Publication: | Darmstadt |
Publisher: | Frontiers |
Collation: | 14 Seiten |
Classification DDC: | 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie |
Divisions: | 10 Department of Biology > Extracellular vesicles / miRNA Research |
Date Deposited: | 04 Aug 2021 08:05 |
Last Modified: | 24 Jun 2022 18:02 |
DOI: | 10.26083/tuprints-00019253 |
Corresponding Links: | |
URN: | urn:nbn:de:tuda-tuprints-192537 |
URI: | https://tuprints.ulb.tu-darmstadt.de/id/eprint/19253 |
PPN: | |
Export: |
![]() |
View Item |