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Biofunctionalization of Silsesquioxane Nanoparticles

Hörner, Sebastian (2017)
Biofunctionalization of Silsesquioxane Nanoparticles.
Technische Universität Darmstadt
Ph.D. Thesis, Primary publication

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Item Type: Ph.D. Thesis
Type of entry: Primary publication
Title: Biofunctionalization of Silsesquioxane Nanoparticles
Language: English
Referees: Kolmar, Professor Harald ; Neumann, Professor Siegfried
Date: 2017
Place of Publication: Darmstadt
Date of oral examination: 27 March 2017
Abstract:

Cube-octameric silsesquioxanes (COSS) were investigated as modular scaffolds for the application in biomedical engineering and associated research areas. Chemical modification of these unique organic-inorganic hybrids endowed them with novel features, aimed at functional tailoring towards executing certain biologic tasks. The chemical and structural peculiarities of COSS nanoparticles were used to address two parallel issues, the first one being development of a viable route to peptide multimers, and the second one – elaboration of a molecular platform for efficient cellular transport.

Alternative Abstract:
Alternative AbstractLanguage

Die Dissertationsarbeit behandelt die Erforschung von Silsesquioxan Gerüstmolekülen im Hinblick auf unterschiedliche biomedizinische Anwendungen. Durch die chemische Modifikation dieser einzigartigen organisch-anorganischen Hybridmoleküle konnten verschiedene biologische Effekte erzielt werden. Dabei wurden die chemischen und strukturellen Besonderheiten von Cube-octameric Silsesquioxanen (COSS) verwendet, um zwei Ziele zu erreichen: Erstens die Etablierung einer geeigneten Methode zur Multimerisierung von Peptiden und zweitens, die Entwicklung einer Plattformtechnologie für effizienten Wirkstofftransport.

German
URN: urn:nbn:de:tuda-tuprints-65658
Classification DDC: 500 Science and mathematics > 500 Science
500 Science and mathematics > 540 Chemistry
600 Technology, medicine, applied sciences > 610 Medicine and health
600 Technology, medicine, applied sciences > 620 Engineering and machine engineering
Divisions: 07 Department of Chemistry
07 Department of Chemistry > Clemens-Schöpf-Institut > Fachgebiet Biochemie
07 Department of Chemistry > Clemens-Schöpf-Institut > Fachgebiet Biochemie > Allgemeine Biochemie
Date Deposited: 30 Jun 2017 14:47
Last Modified: 09 Jul 2020 01:46
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/6565
PPN: 404906044
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