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Non-Natural Elements for Peptide-Based Molecular Design, Structural Analysis, and Functional Modifications

Nasu, Daichi (2016)
Non-Natural Elements for Peptide-Based Molecular Design, Structural Analysis, and Functional Modifications.
Technische Universität Darmstadt
Ph.D. Thesis, Primary publication

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Item Type: Ph.D. Thesis
Type of entry: Primary publication
Title: Non-Natural Elements for Peptide-Based Molecular Design, Structural Analysis, and Functional Modifications
Language: English
Referees: Kolmar, Prof. Harald ; Buntkowsky, Prof. Gerd
Date: 2016
Place of Publication: Darmstadt
Date of oral examination: 14 December 2015
Abstract:

The present thesis summarizes three research projects addressing fundamental studies aimed on application of non-natural elements to design and synthesis of bioactive peptide mimetics, bioconjugates, and hybrid macromolecules. The study comprised computational and knowledge-based design, total synthesis, and evaluation of biologic activity as well as application to NMR-based structural analysis. Results summarized in the present work were reported in two scientific publications and should be considered as milestones for further investigations aimed on application of the discussed concepts to biomedical studies.

Alternative Abstract:
Alternative AbstractLanguage

In der vorliegenden Dissertation sind die Ergebnisse von drei unabhängigen Forschungsprojekten zusammengefasst, die das übergeordnete Thema „Anwendung von unnatürlichen Strukturelementen zur Design und Synthese von bioaktiven Peptiden, Peptidomimetika und Biomakromolekülen“ umfassen. In den jeweiligen Projekten wurden nicht natürliche Strukturelemente für folgende Ziele in unterschiedlichen Biomolekülen eingebaut: 1. Zum molekularem Design von therapeutisch relevanten Wirkstoffen, 2. Zur Markierung für Strukturaufklärung, 3. Zur funktionalen Modifizierungen von Biomakromolekülen. Diese drei Themen wurden individuell bearbeitet und haben Gemeinsamkeiten in der generellen Strategie (Strukturierung in Design, Synthese und Aktivitätsuntersuchung) und der verwendeten Methoden zur Synthese (Peptid-Festphasensynthese, „Click“-Chemie) und Charakterisierung (HPLC, Massen-Spektrometrie, Enzymassays).

German
Uncontrolled Keywords: Peptide, Peptidomimetic, Bioorthogonal Chemistry, Protease Inhibitor, PHIP, Peptide Nucleic Acid
URN: urn:nbn:de:tuda-tuprints-52527
Classification DDC: 500 Science and mathematics > 540 Chemistry
Divisions: 07 Department of Chemistry
07 Department of Chemistry > Clemens-Schöpf-Institut > Fachgebiet Biochemie
Date Deposited: 25 Jan 2016 13:23
Last Modified: 09 Jul 2020 01:13
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/5252
PPN: 386811431
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