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Concepts for millimeter wave-based detection of African trypanosomes in field-compatible liquid systems

Mueh, Mario ; Knieß, Robert ; Göringer, H. Ulrich ; Damm, Christian (2023)
Concepts for millimeter wave-based detection of African trypanosomes in field-compatible liquid systems.
In: Frequenz, 2022, 76 (11-12)
doi: 10.26083/tuprints-00023210
Article, Secondary publication, Publisher's Version

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Item Type: Article
Type of entry: Secondary publication
Title: Concepts for millimeter wave-based detection of African trypanosomes in field-compatible liquid systems
Language: English
Date: 1 March 2023
Place of Publication: Darmstadt
Year of primary publication: 2022
Publisher: De Gruyter
Journal or Publication Title: Frequenz
Volume of the journal: 76
Issue Number: 11-12
DOI: 10.26083/tuprints-00023210
Corresponding Links:
Origin: Secondary publication
Abstract:

Human African Trypanosomiasis (HAT) is caused by the African trypanosome, a single-cell parasite that proliferates in the blood and cerebrospinal fluid of infected patients. Diagnostic measures for this pathogen are currently not sufficiently robust and reliable enough to permit effective disease control procedures. As a consequence, we suggested the development of a new sensor type, combining the selectivity of parasite-specific nucleic acid aptamers with the sensitivity of resonant electromagnetic devices to capture and detect the disease-causing organism. While we accomplished the detection of parasite cells in dehydrated specimens, here we summarize our recent progress toward electromagnetic sensors capable of uncovering parasites in liquid patient samples. We present a technique for the removal of blood cells from blood specimens and the deposition of trypanosome cells on glass microfiber membranes for dielectric spectrometry. Liquid suspensions of trypanosomes are characterized to determine the actual dielectric properties of single parasites and lastly, we present two sensor concepts optimized for the detection in liquids, along with a fabrication technique for the integration of microfluidic sample confinements.

Uncontrolled Keywords: African trypanosomes, biosensors, microfluidics, microwave sensors, neglected diseases, terahertz
Status: Publisher's Version
URN: urn:nbn:de:tuda-tuprints-232102
Classification DDC: 500 Science and mathematics > 530 Physics
500 Science and mathematics > 570 Life sciences, biology
600 Technology, medicine, applied sciences > 610 Medicine and health
600 Technology, medicine, applied sciences > 620 Engineering and machine engineering
Divisions: 10 Department of Biology > Molecular Genetics
18 Department of Electrical Engineering and Information Technology > Institute for Microwave Engineering and Photonics (IMP)
TU-Projects: DFG|GO516/7-2|Aptera II
Date Deposited: 01 Mar 2023 10:11
Last Modified: 28 Sep 2023 11:07
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/23210
PPN: 511934092
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