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Homologous Recombination Subpathways: A Tangle to Resolve

Elbakry, Amira ; Löbrich, Markus (2021):
Homologous Recombination Subpathways: A Tangle to Resolve. (Publisher's Version)
In: Frontiers in Genetics, 12, Frontiers, e-ISSN 1664-8021,
DOI: 10.26083/tuprints-00019438,
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Item Type: Article
Origin: Secondary publication via sponsored Golden Open Access
Status: Publisher's Version
Title: Homologous Recombination Subpathways: A Tangle to Resolve
Language: English
Abstract:

Homologous recombination (HR) is an essential pathway for DNA double-strand break (DSB) repair, which can proceed through various subpathways that have distinct elements and genetic outcomes. In this mini-review, we highlight the main features known about HR subpathways operating at DSBs in human cells and the factors regulating subpathway choice. We examine new developments that provide alternative models of subpathway usage in different cell types revise the nature of HR intermediates involved and reassess the frequency of repair outcomes. We discuss the impact of expanding our understanding of HR subpathways and how it can be clinically exploited.

Journal or Publication Title: Frontiers in Genetics
Journal volume: 12
Publisher: Frontiers
Collation: 7 Seiten
Classification DDC: 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie
Divisions: 10 Department of Biology > Radiation Biology and DNA Repair
Date Deposited: 03 Sep 2021 12:33
Last Modified: 03 Sep 2021 12:34
DOI: 10.26083/tuprints-00019438
Corresponding Links:
URN: urn:nbn:de:tuda-tuprints-194381
Additional Information:

Keywords: homologous recombination, pathway choice, synthesis-dependent strand annealing, ATRX, RECQ5, double-strand break, holliday junction, crossover

URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/19438
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