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Roles, Characteristics, and Analysis of Intrinsically Disordered Proteins: A Minireview

Lermyte, Frederik (2021):
Roles, Characteristics, and Analysis of Intrinsically Disordered Proteins: A Minireview. (Publisher's Version)
In: Life, 10 (12), MDPI, e-ISSN 2075-1729,
DOI: 10.26083/tuprints-00019275,
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Item Type: Article
Origin: Secondary publication via sponsored Golden Open Access
Status: Publisher's Version
Title: Roles, Characteristics, and Analysis of Intrinsically Disordered Proteins: A Minireview
Language: English
Abstract:

In recent years, there has been a growing understanding that a significant fraction of the eukaryotic proteome is intrinsically disordered, and that these conformationally dynamic proteins play a myriad of vital biological roles in both normal and pathological states. In this review, selected examples of intrinsically disordered proteins are highlighted, with particular attention for a few which are relevant in neurological disorders and in viral infection. Next, the underlying causes for intrinsic disorder are discussed, along with computational methods used to predict whether a given amino acid sequence is likely to adopt a folded or unfolded state in solution. Finally, biophysical methods for the analysis of intrinsically disordered proteins will be discussed, as well as the unique challenges they pose in this context due to their highly dynamic nature.

Journal or Publication Title: Life
Journal volume: 10
Number: 12
Publisher: MDPI
Collation: 19 Seiten
Classification DDC: 500 Naturwissenschaften und Mathematik > 540 Chemie
Divisions: 07 Department of Chemistry > Fachgebiet Biochemie
Date Deposited: 09 Aug 2021 08:01
Last Modified: 09 Aug 2021 08:01
DOI: 10.26083/tuprints-00019275
Corresponding Links:
URN: urn:nbn:de:tuda-tuprints-192758
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/19275
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