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Extracellular miR-574-5p Induces Osteoclast Differentiation via TLR 7/8 in Rheumatoid Arthritis

Hegewald, Anett B. ; Breitwieser, Kai ; Ottinger, Sarah M. ; Mobarrez, Fariborz ; Korotkova, Marina ; Rethi, Bence ; Jakobsson, Per-Johan ; Catrina, Anca I. ; Wähämaa, Heidi ; Saul, Meike J. (2021)
Extracellular miR-574-5p Induces Osteoclast Differentiation via TLR 7/8 in Rheumatoid Arthritis.
In: Frontiers in Immunology, 2020, 11
doi: 10.26083/tuprints-00019253
Article, Secondary publication, Publisher's Version

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Item Type: Article
Type of entry: Secondary publication
Title: Extracellular miR-574-5p Induces Osteoclast Differentiation via TLR 7/8 in Rheumatoid Arthritis
Language: English
Date: 2021
Place of Publication: Darmstadt
Year of primary publication: 2020
Publisher: Frontiers
Journal or Publication Title: Frontiers in Immunology
Volume of the journal: 11
Collation: 14 Seiten
DOI: 10.26083/tuprints-00019253
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Origin: Secondary publication via sponsored Golden Open Access
Abstract:

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation and joint destruction. Cell-derived small extracellular vesicles (sEV) mediate cell-to-cell communication in the synovial microenvironment by carrying microRNAs (miRs), a class of small non-coding RNAs. Herein, we report that sEV from synovial fluid promote osteoclast differentiation which is attributed to high levels of extracellular miR-574-5p. Moreover, we demonstrate for the first time that enhanced osteoclast maturation is mediated by Toll-like receptor (TLR) 7/8 signaling which is activated by miR-574-5p binding. This is a novel mechanism by which sEV and miRs contribute to RA pathogenesis and indicate that pharmacological inhibition of extracellular miR-574-5p might offer new therapeutic strategies to protect osteoclast-mediated bone destruction in RA.

Status: Publisher's Version
URN: urn:nbn:de:tuda-tuprints-192537
Classification DDC: 500 Science and mathematics > 570 Life sciences, biology
Divisions: 10 Department of Biology > Extracellular vesicles / miRNA Research
Date Deposited: 04 Aug 2021 08:05
Last Modified: 24 Jun 2022 18:02
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/19253
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