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A Process of Resection-Dependent Nonhomologous End Joining Involving the Goddess Artemis

Löbrich, Markus ; Jeggo, Penny (2021):
A Process of Resection-Dependent Nonhomologous End Joining Involving the Goddess Artemis. (Publisher's Version)
In: Trends in Biochemical Sciences, 42 (9), pp. 690-701. Elsevier, ISSN 0968-0004,
DOI: 10.26083/tuprints-00018935,
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Item Type: Article
Origin: Secondary publication service
Status: Publisher's Version
Title: A Process of Resection-Dependent Nonhomologous End Joining Involving the Goddess Artemis
Language: English
Abstract:

DNA double-strand breaks (DSBs) are a hazardous form of damage that can potentially cause cell death or genomic rearrangements. In mammalian G1- and G2-phase cells, DSBs are repaired with two-component kinetics. In both phases, a fast process uses canonical nonhomologous end joining (c-NHEJ) to repair the majority of DSBs. In G2, slow repair occurs by homologous recombination. The slow repair process in G1 also involves c-NHEJ proteins but additionally requires the nuclease Artemis and DNA end resection. Here, we consider the nature of slow DSB repair in G1 and evaluate factors determining whether DSBs are repaired with fast or slow kinetics. We consider limitations in our current knowledge and present a speculative model for Artemis-dependent c-NHEJ and the environment underlying its usage.

Journal or Publication Title: Trends in Biochemical Sciences
Journal volume: 42
Number: 9
Publisher: Elsevier
Classification DDC: 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie
Divisions: 10 Department of Biology > Radiation Biology and DNA Repair
Date Deposited: 16 Aug 2021 12:13
Last Modified: 16 Aug 2021 12:14
DOI: 10.26083/tuprints-00018935
Corresponding Links:
URN: urn:nbn:de:tuda-tuprints-189353
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/18935
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